RITUXAN 100mg is indicated for the treatment of adult patients with: Relapsed or refractory, low-grade or follicular, CD20-positive, B-cell NHL as a single agent. Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete
- Non-Hodgkin lymphoma. RITUXAN 100mg treats some forms of a cancer called non-Hodgkin lymphoma (NHL) that are CD20-positive and affect cells known as B cells. The drug can be used alone or with other medications:
- Rituxan for NHL when used alone. For this use, the cancer must be either low grade (slow spreading) or a kind called follicular lymphoma (FL). Also, the cancer must be relapsed or refractory. “Relapsed” means that the cancer came back after previous treatment. And “refractory” means that the cancer hasn’t gotten better with other treatments. For this purpose, Rituxan is used alone.
- Rituxan for NHL when used with chemotherapy. For this use, the cancer must be FL that hasn’t been treated before. Also for this use, Rituxan is used with chemotherapy. If you have this treatment and have a partial or complete response* to it, your doctor may have you then use Rituxan alone.
- Rituxan for NHL when used after CVP chemotherapy. For this use, the cancer must be low grade. The cancer must also be non-progressing, which means that it didn’t worsen after you tried chemotherapy with the drugs cyclophosphamide, vincristine, and prednisone (Rayos). For this purpose, Rituxan is used alone.
- Rituxan for diffuse large B-cell lymphoma. For this use, the diffuse large B-cell lymphoma (DLBCL)must not have been treated before. Also for this use, Rituxan is used with the medications cyclophosphamide, doxorubicin, vincristine, and prednisone, or with other chemotherapy drugs called anthracyclines.
- Chronic lymphocytic leukemia. Chronic lymphocytic leukemia (CLL) is a type of blood cancer. Rituxan is used for CLL that’s CD20-positive and has or hasn’t been previously treated. For this purpose, Rituxan is used with the drugs fludarabine and cyclophosphamide.
- Rheumatoid arthritis. With rheumatoid arthritis (RA), your body mistakenly attacks its own joints. For this purpose, Rituxan is used with methotrexate (Trexall) to treat RA that’s moderate to severe and active. “Active” means that you currently have symptoms. You must have tried a drug known as a tumor necrosis factor (TNF) antagonist, but you weren’t able to tolerate its side effects or the medication didn’t relieve your symptoms.
- Granulomatosis with polyangiitis.† Granulomatosis with polyangiitis (GPA) is a condition in which your blood vessels become swollen and damaged. For this purpose, Rituxan is used with drugs called glucocorticoids.
- Microscopic polyangiitis.† Like GPA, microscopic polyangiitis (MPA) is a condition in which your blood vessels become swollen and damaged. For this purpose, Rituxan is used with drugs called glucocorticoids.
- Pemphigus vulgaris. Pemphigus vulgaris is a condition in which your skin and mucous membranes develop serious and painful blisters. (Mucous membranes line areas such as the mouth and are protected with mucus.) For this use, Rituxan treats pemphigus vulgaris that’s moderate to severe.
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